منابع مشابه
Heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular FcγRIIA on platelets and monocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis. It is now recognized that anti-PF4/heparin antibodies devel...
متن کاملHeparin induced thrombocytopenia
Heparin induced thrombocytopenia (HIT) is a prothrombotic syndrome initiated by platelet-activating auto-antibodies with potentially devastating complications. Once the diagnosis of HIT is suspected, discontinuation of heparin and treatment with an alternative anticoagulant are mandatory. While established drugs for HIT are no longer available, parenteral factor Xa inhibitors, thrombin inhibito...
متن کاملHeparin-induced Thrombocytopenia
Nebojša M. Antonijević1, Nebojša Radovanović1, Slobodan Obradović2, Dragica Vučelić6, Bojan Stojanović1, Danijela Miković4, Mirjana Kovač4, Tina Kočica1, Svetlana Tadić4, Irina Antonijević4, Snežana Drašković4, Valentina Djordjević5, Branko Čalija6, Jovan Peruničić1, Zorana Vasiljević1 1 Institute of Cardiovascular Diseases, Clinical Centre of Serbia, Belgrade, Serbia; 2 Clinic of Emergency Med...
متن کاملHeparin-induced thrombocytopenia.
Each year, 25% of all hospitalized patients are affected by venous thromboembolism, a disease comprising deep vein thrombosis and pulmonary embolism, that is responsible for up to 10% of all inpatient deaths (Alikhan, Peters, Wilmott, Cohen, 2004). Used in both the treatment and the prevention of venous thromboembolism, heparin is administered to more than 12 million patients each year in the U...
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ژورنال
عنوان ژورنال: Medicina
سال: 2008
ISSN: 1648-9144
DOI: 10.3390/medicina44090093